Protein Details: Voltage-gated sodium channel subunit beta-4

Protein ID

ICDB_Pro_1254

Protein Name

Voltage-gated sodium channel subunit beta-4

Gene Name

SCN4B

Organism

Homo sapiens (Human)

Length

228 amino acids

AlphaFoldDB

AF-Q8IWT1-F1-model_v4.pdb

Function

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels; but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider; scorpion; wasp and sea anemone venom.

Sequence

MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKATDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDDDRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEVDNTVTLIILAVVGGVIGLLILILLIKKLIIFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPSKV

PDB Structures

4MZ2 4MZ3 5XAW 6VSV 7DTD

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Long Qt Syndrome 10 and Long Qt Syndrome 1

Location

heart; skeletal muscle; central and peripheral neurons

DOI ID

10.1038/nature04632; 10.1073/pnas.1314557110

RefSeq

NP_001135820.1 [Q8IWT1-3]; NP_001135821.1 [Q8IWT1-2]; NP_777594.1 [Q8IWT1-1]